Mesothelioma In The News


Mesothelioma -- The clinicopathological characteristics with long-term outcomes in malignant mesothelioma 

Medical Oncology,   Clinical Article

Dogan M, et al. – Malignant mesothelioma (MM) is a neoplasm which originates from serous membranes. It is relatively more common in Turkey. Most preferred CT regimen was cisplatinum and pemetrexed. Most of the patients were male in their 50 s with pleural MM. They had chest pain, dyspnea, weight loss and loss of appetite as the most common symptoms at diagnosis. Only half of the patients could be subtyped with a predominance of epitheloid histology.


Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area 
Genes, Chromosomes and Cancer,   Clinical Article

Betti M, et al. – In this study, the authors report the analysis of BAP1 in five multiplex MM families and in 103 sporadic cases of MM. The data show that BAP1 mutations are very rare in patients with sporadic MM, and they report a new BAP1 mutation, extend the cancer types associated with these mutations, and suggest the existence of other yet unknown genes in the pathogenesis of familial MM.

A multicentre non-blinded randomised controlled trial to assess the impact of regular early specialist symptom control treatment on quality of life in malignant mesothelioma (RESPECT-MESO): study protocol for a randomised controlled trial Full Text 


Trials, 

Gunatilake S, et al. – Current practice in the United Kingdom is to involve specialist palliative care towards the final weeks or months of a life–limiting illness. This study aims to investigate whether early, regular specialist care input can result in significant health related quality of life gains for patients with mesothelioma and if this change in treatment model is cost–effective. The results will be widely applicable to many institutions and patients both in the United Kingdom and internationally.





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